Lack of a Hypoglycemic Response to Intrathecal Injection of Glucose.

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Abstract
The hypothesis of Mar-inelli and Giunti that increases in the spinal fluid glucose level induce a rapid and pronounced reduction in the peripheral blood sugar level was tested in a series of human subjects. Intracisternal injn. of 5% glucose soln. resulted in marked increases in the glucose concn. in the spinal fluids withdrawn from the lumbar level. Such findings were interpreted as indicative of free diffusion of glucose throughout the sub-arachnoid spaces. Blood sugar values were detd. at 15 min. intervals for 1 hr. after the intraspinal injn. In no case was a significant decrease in blood sugar observed. It was concluded that increases in the spinal fluid glucose do not influence any mechanisms that may be involved in the regulation of carbohydrate metabolism by the C. N. S.

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