Arthritis in patients with psoriasis is associated with an immunoglobulin gene polymorphism
- 1 February 1988
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 31 (2) , 276-278
- https://doi.org/10.1002/art.1780310217
Abstract
Using a DNA probe for the switch region of immunoglobulin heavy chain genes, together with the restriction endonuclease Sst I, we detected a particular polymorphic DNA pattern in 17 of 28 patients (60.7%) with psoriatic arthropathy but in only 5 of 41 patients (12.2%) with psoriasis alone. Our findings suggest that genes in the immunoglobulin region confer susceptibility to the development of arthropathy in patients with psoriasis.Keywords
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