Studies on chemotaxis. XII. Generation of chemotactic activity for polymorphonuclear leucocytes in sera with complement dificiencies.

  • 1 February 1969
    • journal article
    • Vol. 16  (2) , 231-9
Abstract
The significance of the C′ system for chemotaxis of rabbit PMNs was studied in vitro. C′6-deficient rabbit sera and C′5-deficient mouse sera were compared with normal rabbit and mouse sera for their ability to generate chemotactic factors in the presence of antigen—antibody complexes and endotoxins. No difference could be detected between these C′-deficient and normal sera. Full chemotactic activity was observed even when a rabbit anti-C′6 serum was incubated with an antigen—antibody complex. These results are incompatible with C′ (5, 6, 7)a being the chemotactic factor in serum for polymorphonuclear leucocytes.