Synthesis of Phosphopeptides. V. Further Dipeptides, Tripeptides and O-Phosphorylated Derivatives of L-Serine.
- 1 January 1966
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 20 (2) , 459-473
- https://doi.org/10.3891/acta.chem.scand.20-0459
Abstract
Di- and tripeptides, having the sequences Asp-Ser P, Glu(SerP), Ile-SerP, Lys-SerP, SerP-Ala, SerP-His, Asp-SerP-Gly, Asp-SerP-Ala, Asp-SerP-Glu, Glu-SerP-Gly, Glu-SerP-Ala, and Leu-Gly-SerP, as well as the corresponding phosphate-free peptides were synthesized via N-benzyloxy-carbonyl peptide benzyl esters. It was observed, that protected dipep-tide and tripeptide derivatives of [beta]-benzyl-aspartylserine all underwent a rapid cyclization to aspartimides under weakly alkaline conditions, e. g. when dissolved in pyridine-water, whereas the corresponding [gamma]-benzyl-glutamylserine derivatives were stable under the same conditions. Some further new derivatives of serine and threonine were prepared and studied.This publication has 10 references indexed in Scilit:
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