TURNOVER RATE AND OXIDATION OF FREE FATTY ACIDS OF BLOOD PLASMA IN MAN DURING EXERCISE: STUDIES DURING CONTINUOUS INFUSION OF PALMITATE-1-C14*

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Abstract
The turnover rate of the free fatty acids and the concentration of glycerol in blood plasma were greatly increased during exercise in a group of fasting athletes. Almost half of the respiratory CO2 was derived from rapid oxidation of free fatty acids. Glucose feeding produced a 4- to 5-fold reduction in the turnover rate and oxidation of free fatty acids. The results suggest that in the postabsorptive state free fatty acids mobilized from adipose tissue are the major fuel delivered to working muscle from the blood. Decreased mobilization of free fatty acids after feeding carbohydrate accounted almost entirely for their decreased oxidation during muscular work.