Crystal Structure of A Z-DNA Fragment Containing Thymine/2-Aminoadenine Base Pairs
- 1 October 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Biomolecular Structure and Dynamics
- Vol. 4 (2) , 157-172
- https://doi.org/10.1080/07391102.1986.10506337
Abstract
The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-ammoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 Å resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.This publication has 17 references indexed in Scilit:
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