Cyanide Poisoning

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Abstract
The increasing use of Laetrile has been added to the traditional sources of exposure to cyanide in industry, chemistry labs and fumigation. The events in Jonestown [Guyana] in 1978 were a grim reminder of the lethality of cyanide. Advancement in new modes of treatment has been slow. The traditional method of treatment used in the USA is effective but not without its own morbidity and mortality. Using 2 case reports as models, the topic of cyanide poisoning was reviewed including sources of exposure, pathophysiology, clinical manifestations of acute and chronic exposure and modes of treatment. Although there is currently no accepted alternate treatment in the USA, review of the literature shows promise in other modalities being investigated in Europe, including hydroxocobalamin, Cobalt salts and aminophenol.

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