Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.

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Abstract
Chemically synthesised CH3Sp(A2′p)2A2′pp3′OCH3 has been used to assess the importance of the ppp(A2′p)nA (n greater than or equal to 2: 2‐5A) system in the antiviral action of interferon against encephalomyocarditis virus (EMC). It inhibits activation of the 2‐5A‐dependent RNase by 2‐5A in intact mouse L929 cells and cell‐free systems. In interferon‐treated, EMC‐infected L929 cells it inhibits 2‐5A‐mediated rRNA cleavage and partially restores EMC RNA synthesis and virus yield. Activation of the 2‐5A‐dependent RNase must, therefore, play some part in interferon action against the growth of EMC virus in such cells.