CHANGES IN CIRCULATING EOSINOPHILES AND ADRENAL ASCORBIC ACID CONCENTRATION AFTER AGENTS ALTERING BLOOD SUGAR LEVELS AND AFTER SURGICAL CONDITIONS

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Abstract
The change in number of circulating eosinophiles was detd. and tested for statistical significance in groups of rats subjected to the following procedures: ablation of the adrenal glands, spleen, or both organs; after the injn. of epinephrine (0.02 mg./100 g. of rat) in adrenalectomized, splenectomized, or adrenalectomized-splenectomized rats; after an overnight or 48 hr. fast of normal intact rats; and after the admn. of epinephrine, insulin (0.5 U. subcut/rat) or glucose per os (2 ml. of a 50% soln.) in normal intact rats. A significant increase in eosinophiles/cu. mm. of blood was induced in those untreated groups in which the spleen was absent; after epinephrine in adrenalectomized rats; and 60 min. after insulin injn. in intact rats. A significant decrease in the number of eosinophiles/cu. mm. of blood was induced only in those groups of rats in which the adrenal glands were in situ 180 min. after epinephrine, insulin, or glucose per os, but not after shorter intervals of agent admn.; and after an overnight fast. A relationship of induced eosinopenia with a significant depletion of the adrenal ascorbic acid was demonstrated only in 2 groups of rats 180 min. after the injn. of epinephrine or insulin. Significant changes in the eosinophilic leucocyte picture were not associated with significant change in adrenal ascorbic acid concn.