STANDARDIZED HEMORRHAGIC SHOCK IN THE GUINEA PIG

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Abstract
A method is described for the standardization of hemorrhagic shock in the unanesthetized guinea pig as well as in barbiturized animals. The results are compared. The method consists of letting the heparinized animal lose blood from a cannulated artery, the flow being completely unhampered; neither the magnitude nor the duration of the hemorrhage is regulated. Once cardiorespiratory failure is imminent, 25% of the bleeding vol. is returned to the circulation; at the 2d collapse, the remainder of the blood is transfused. The mortality rate of 32 unanesthetized guinea pigs was 94%, and was 81% in 21 barbiturized animals. On the avg., unanesthetized animals lost 4.8% of their body wt. of blood in 24 min. (1st stage); the hypotension was prolonged for 16 min. (2d stage). Anesthetized animals lost more blood, at a slower rate, and survived longer. The importance of factors such as room temp., position, and immobilization of the animal is stressed.

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