THE DIURETIC ACTION OF THYROID IN DIABETES INSIPIDUS

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Abstract
The renal response to thyroid feeding was measured by creatinine, inulin and urea clearances, urine flow, chloride excretion and reabsorption, and by the maximal rate of tubular reabsorption of glucose in (1) normal dogs and in dogs with (2) severe and (3) latent diabetes insipidus. Glomerular fitration was approx. doubled in all animals. In group 1 the urine flow was only slightly increased; in group 2 it was increased by about the same % as glomerular filtration; in group 3 it was increased as much as 40 fold. This suggested that in hyper-thyroidism the antidiuretic hormone is less effective. This was demonstrated in dogs of group 2 in which the threshold to pituitrin was greatly elevated when they were receiving thyroid. Chloride excretion was not significantly affected, while urea clearances and urea excretion were elevated. The increase in glucose Tm, which parallels the increase in glomerular filtration, may be due to a recruitment of nephrons or to a facilitation of the tubular mechanism for glucose transfer.