Thyroid and vitamin B1

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Abstract
Subcut. inj. of vit. B1, gave protection from the loss in wt. produced in rats by thyroxine injs. A pretreatment with vit. B1 also lessens the rate at which thyroid-fed rats fall in wt. Catatorulin effects are obtained with brain tissue from hyperthyroid animals but not from normal animals on the same diet. Catatorulin effects, abolished by previous inj. of the animal with vit. B1, are obtained with kidney tissue from both hyperthyroid and normal animals fed on a basal diet containing small but adequate amts. of vit. B1. The cocarboxylase content of boiled tissue extracts from hyperthyroid animals is intermediate in value between those from normal animals and those from animals showing symptoms of vit. B1 deficiency. Inj. of vit. B1 increases the cocarboxylase content of the tissues of both normal and hyperthyroid animals. After 7 days of pretreatment with vit. B1 the cocarboxylase content of the tissues falls more rapidly in hyperthyroid than in normal animals.

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