Amiodarone-induced hypothyroidism. A common complication of prolonged therapy: a report of eight cases
- 1 June 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 145 (6) , 1016-1019
- https://doi.org/10.1001/archinte.145.6.1016
Abstract
Amiodarone is a widely used antiarrhythmic drug, [for cardiac arrhythmia], which contains 75 mg of I- per 200 mg of active substance. Eight patients receiving long-term amiodarone therapy experienced hypothyroidism. Of these patients 7 had no previous history of thyroid dysfunction or goiter. Antithyroid antibodies were absent and standard perchlorate discharge tests were positive in 7 patients when hypothyroidism was diagnosed. In 1 patient, amiodarone therapy was withdrawn; over the next 9 mo., the hypothyroidism resolved and results of the perchlorate discharge test reverted to normal. Amiodarone-induced hypothyroidism is similar to previously described I--induced hypothyroidism. It may develop in the absence of a previous history of thyroid disease and all patients receiving long-term amiodarone therapy should therefore be regularly monitored for hypothyroidism.This publication has 12 references indexed in Scilit:
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