Graft‐derived anti‐HPA‐2b production after allogeneic bone‐marrow transplantation
- 12 March 1994
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 86 (3) , 651-653
- https://doi.org/10.1111/j.1365-2141.1994.tb04801.x
Abstract
We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.Keywords
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