Consanguinity and the genetic control of Down syndrome
- 1 January 1990
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 37 (1) , 24-29
- https://doi.org/10.1111/j.1399-0004.1990.tb03386.x
Abstract
Eighty-three infants and children with a professional diagnosis of Down syndrome were studied cytogenetically. The results showed that 81.9% of them were trisomy 21 and 18.1% were the 46/47 + G type of mosaic. All cases were distributed according to parental consanguinity. The results showed that 77.9%, 16.2% and 5.9% of the trisomy 21 cases, and 53.3%, 26.7% and 20.0% of the mosaic cases were from non-consanguineous, first-cousin and second-cousin marriages, respectively. By combining all the cases, these percentages were 73.5%, 18.1% and 8.4%, respectively. Considering the high rate of inbreeding in Iraq (inbreeding coefficient = 0.0225) and using various statistical comparisons, these results revealed the lack of evidence for genetical control of non-disjunction in man.Keywords
This publication has 14 references indexed in Scilit:
- Consanguinity and Reproductive Health in IraqHuman Heredity, 1989
- The Causes of Down SyndromeScientific American, 1987
- International commission for protection against environmental mutagens and carcinogensMutation Research Letters, 1986
- Aspects of NondisjunctionPublished by Springer Nature ,1984
- Variation in pattern and frequency of acrocentric association in normal and trisomy-21 individualsHuman Genetics, 1981
- Inbreeding and the genetic control of nondisjunctionHuman Genetics, 1981
- Relationships between satellite association and the occurence of non-disjunction in manMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
- Etiology of nondisjunction: lack of evidence for genetic controlCytogenetic and Genome Research, 1970
- Leukocytes Cultured from Small Inocula of Whole Blood and the Preparation of Metaphase Chromosomes by Treatment with Hypotonic KCLStain Technology, 1965