Inbreeding and the genetic control of nondisjunction
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 59 (2) , 125-128
- https://doi.org/10.1007/bf00293060
Abstract
We have studied the frequency of trisomics in newly formed zygotes and the proportion of trisomics, k, coming from consanguineous marriages by assuming that recessive genes at a single locus or multiple loci are responsible for the induction of nondisjunction. For mitotic nondisjunction, the value of k increases as the magnitude of consanguinity of the parents increases, but the opposite relationship holds for meiotic nondisjunction. Therefore, it is important to distinguish mitotic and meiotic types in the genetic study of nondisjunction. This seems to be one of the simples tests for detecting the genetic control of nondisjunction.This publication has 8 references indexed in Scilit:
- The relative effects of paternal and maternal age in mongolismJournal of Genetics, 2009
- Recurrence risks for down syndromeHuman Genetics, 1980
- EVIDENCE FOR GENETIC-CONTROL OF NONDISJUNCTION IN MAN1980
- Down's syndromeHuman Genetics, 1971
- Etiology of nondisjunction: lack of evidence for genetic controlCytogenetic and Genome Research, 1970
- Down's Syndrome and Maternal InbreedingActa geneticae medicae et gemellologiae, 1966
- RECESSIVE GENES IN SEVERE MENTAL DEFECT1965
- The relative effects of paternal and maternal age in mongolismJournal of Genetics, 1933