THE COÖPERATIVE ACTION OF SYMPATHETIC NERVE IMPULSES, ADRENINE AND SYMPATHIN ON THE NICTITATING MEMBRANE OF THE CAT

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Abstract
Summation of different sympathetic components[long dash]direct sympathetic nerve impulses, sympathin from other sources, and adrenine[long dash]was studied by their simultaneous effects on the nictitating membrane of cocainized cats. A cooperation of these diverse stimuli was found as indicated by effective summation of all combinations of 2 or 3 tried. A subminimal chemical stimulus, e.g., sympathin, is capable of increasing the response to either of the other excitatory agents. The method, therefore, affords an opportunity to reveal minute amounts of sympathin, otherwise undetectable.

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