THE INFLUENCE OF THIOURACIL ON REPRODUCTION AND GROWTH IN THE RAT
- 1 October 1949
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 6 (2) , 137-+
- https://doi.org/10.1677/joe.0.0060137
Abstract
Fertility is markedly reduced in adult female rats rendered hypothyroid by a diet containing 0.2% thiouracil fed for 10 wks. This was explained on the basis of altered estrus cycles. Cretinoid young were obtained from these females and were maintained at a stage of incomplete development for periods up to 16 mos. by continuing the diet of 0.2% thiouracil. These animals have large, colloid-free thyroids, low plasma protein iodide values and B. M. R.''s lowered by 20-35%. The withdrawal of the thiouracil results in a temporary renewal of growth and a rapid restoration of reproductive activity. The thyroid recovers its ability to store thyroglobulin and to restore the B. M. R. The plasma level of hormone does not return to normal.Keywords
This publication has 9 references indexed in Scilit:
- DETERMINATION OF PROTEIN-BOUND IODINEJournal of Biological Chemistry, 1948
- THE INFLUENCE OF HYPOPHYSECTOMY UPON PLASMA IODINE AND THYROXINE CONTENT OF THE THYROID GLAND OF THE RAT1Endocrinology, 1946
- HYPERTHYROIDISM AND THIOURACILAnnals of Internal Medicine, 1945
- THIOURACIL. ITS ABSORPTION, DISTRIBUTION, AND EXCRETION 1Journal of Clinical Investigation, 1944
- Further Studies of the Absorption, Distribution, and Elimination of Thiouracil1Journal of Clinical Endocrinology & Metabolism, 1944
- The Protein-Bound Plasma Iodine in Patients with Thyroid DiseaseJournal of Clinical Endocrinology & Metabolism, 1944
- CRETINISM IN RATS INDUCED BY THIOURACIL1Endocrinology, 1944
- BEGINNING OF FUNCTION IN THE THYROID OF THE FETAL RATEndocrinology, 1943
- PROTEIN-BOUND IODINE IN BLOOD.The Lancet Healthy Longevity, 1941