Application of Glycodiversification: Expedient Synthesis and Antibacterial Evaluation of a Library of Kanamycin B Analogues
- 25 March 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (9) , 1381-1384
- https://doi.org/10.1021/ol0497685
Abstract
The expedient synthesis of a library of kanamycin B analogues is reported. The revealed SAR will guide future designs in developing kanamycin-type aminoglycoside antibiotics against drug-resistant bacteria.Keywords
This publication has 8 references indexed in Scilit:
- Application of the Synthetic Aminosugars for Glycodiversification: Synthesis and Antimicrobial Studies of PyranmycinThe Journal of Organic Chemistry, 2004
- Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter ResistanceAntimicrobial Agents and Chemotherapy, 2000
- Metal catalyzed diazo transfer for the synthesis of azides from aminesTetrahedron Letters, 1996
- An improved synthesis of 3′,4′-dideoxykanamycin BCarbohydrate Research, 1982
- AMINOGLYCOSIDE ANTIBIOTICS. 5. REGIOSPECIFIC SYNTHESIS OF 1-N-[(S)-4-AMINO-2-HYDROXYBUTYRYL]- 2"-DEOXYKANAMYCIN B FROM NEAMINEThe Journal of Antibiotics, 1982
- Aminoglycoside antibiotics. 2. N, N-DialkylkanamycinsJournal of Medicinal Chemistry, 1979
- Chemical modification of aminocyclitol antibioticsCarbohydrate Research, 1976
- Crystal and Molecular Structure of ω-Amino Acids, ω-Aminosulfonic Acids and Their Derivatives. I. The Crystal and Molecular Structure of γ-Guanidinobutyric Acid Hydrochloride and HydrobromideBulletin of the Chemical Society of Japan, 1972