ENDOTHELIAL INJURY AND REGENERATION .4. ENDOTOXIN - A NONDENUDING INJURY TO AORTIC ENDOTHELIUM
- 1 January 1983
- journal article
- research article
- Vol. 48 (1) , 25-34
Abstract
Groups of rats were injected with endotoxin (Escherichia coli, 3 mg/kg of body wt) over a 10 min period and perfusion fixed at 0.5, 1, 2, 4, 8, 18, 20, 24, 48, 72 and 96 h later. Studies on aortic endothelium of these animals revealed no endothelial cell denudation and no exposure of the subendothelium. By 20 h many cells had attached to the intact endothelial monolayer; some of these cells could be identified as desquamating endothelial cells. Autoradiographs revealed a marked increase in endothelial cell replication between 24-96 h. Since there was no change in the number of cells per unit area, endotoxin in the rat produces desquamation with simultaneous replacement by cell movement and cell replication.This publication has 11 references indexed in Scilit:
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