OBSERVATIONS ON PHOSPHATE TRANSPORT IN EXPERIMENTAL RENAL DISEASE*

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Abstract
Patterns of phosphate excretion were studied in dogs with various forms of unilateral renal disease. Phosphate reabsorption per unit of glomerular filtration rate (GFR) transport maximum of phosphate per unit GFR were essentially the same in the diseased kidneys and the contralateral control organs. The data indicate that experimental renal disease is not associated with failure of phosphate transport and suggest that the abnormal patterns of phosphate excretion in bilateral human renal disease result from adaptive changes induced by the uremic state.