ANTI-HUMAN CYTOMEGALOVIRUS NUCLEAR ANTIGEN ANTIBODIES OF DIFFERENT IMMUNOGLOBULIN CLASSES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 26  (1-2) , 73-78
Abstract
IgG, IgM and IgA Ig classes of antibodies to human cytomegalovirus nuclear antigens (CMNA) were studied by the acid-fixed nuclear binding technique (AFNB) and combined anti-complement immunofluorescence (combined ACIF). In acute cases of infectious mononucleosis (IM) of human cytomegalovirus (HCMV) origin and in the so-called double virus infections (HCMV + Epstein-Barr virus), anti-CMNA IgM antibodies were detected. They were absent from both anti-HCMV positive sera of healthy donors and sera of patients suffering of IM caused by EBV used as controls. The presence of CMNA IgM may thus serve as an additional evidence of acute HCMV infection. Non-complement-fixing IgA classes of the anti-CMNA antibodies were not found in some of the sera gathered during the acute phase of IM of EBV origin: in 1/4 of the HCMV seropositive donors and in a number of late serum samples; however, non-complement-fixing and complement-fixing anti-CMNA components of the IgG class were detected.