ACTION OF PATHOLOGICAL THYROIDS FROM RABBITS AND SHEEP ON METABOLISM AND HEART RATE IN THYROIDECTOMIZED RATS

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Abstract
The investigation of goitrous thyroids from rabbits and sheep shows that the metabolic effect in assays on thyroidectomized rats depends on the presence of I and colloid. Glands of the type investigated, containing colloid, had little effect on the heart rate. In actively hyperplastic glands without colloid the heart stimulating factor may be present with more or less complete absence of metabolic effect. A single feeding of I to a rabbit having the latter type of gland, within two days, led to an accumulation of I in the gland and a proportionate appearance of metabolic hormone, but without demonstrable change in the quantity of the heart accelerator factor. Sheep thyroid glands with actively hyperplastic structure and no colloid showed no demonstrable physiologic effects in the test animal.