Genetic control of murine IgD structural heterogeneity.

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Abstract
Murine B [bone marrow-derived] lymphocytes express 2 native forms of surface IgD: IgDI consists of 2 .delta. H chains and 2 L chains; IgDII consists of 1 H chain and 1 L chain. The relative amounts of IgDI and IgDII present on spleen cells varied significantly among different strains of mice. Genetic evidence demonstrated that the IgDI/IgDII ratio is linked to the Igh-5 allotype. (The .delta. H chain is the product of the Igh-5 locus). Mice bearing the Igh-5e allotype have a low ratio, and mice bearing the Igh-5a allotype have a high ratio. The Igh-5 locus and the gene controlling the IgDI/IgDII ratio appear to map to the region between the Igh-6 and Igh-V loci.