Assay of Brain Tocopherols Using High Performance Liquid Chromatography

Abstract
The four natural tocopherols were separated using a μ-Bondapak-NH2 column. For the analysis of brain tocopherols 5,7-dimethyltocol was used as an internal standard. α-Tocopherylquinone and other tocopherols than α-tocopherol were not detected. Rat cerebral cortex and cerebellum contained 19.3 μmol/g and 11.2 μmol/g of α-tocopherol, respectively. A chromatographic system with a reversed-phase column proved less suitable.