The immune response of allophenic mice to 2,4-dinitrophenyl (DNP)-bovine gamma globulin. I. Allotype analysis of anti-DNP antibody

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Abstract
The immune response of allophenic mice to an antigen, DNP-bovine .gamma.-globulin (DNP56BGG), known to be controlled by genes inside and outside the H-2 complex, was tested. When high and low responder cells to DNP56BGG are present in allophenic mice, only antibody of the high responder allotype is produced. Apparently, cell cooperation in allophenic mice cannot occur across a histocompatibility difference barrier in response to an antigen whose genetic control is at least partially within the H-2 complex.

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