Analysis of the Gene Polymorphism of ABO Blood Group Specific Transferases Helps Diagnosis of Acquired B Status
- 5 March 1992
- journal article
- case report
- Published by Wiley in Vox Sanguinis
- Vol. 62 (2) , 113-116
- https://doi.org/10.1111/j.1423-0410.1992.tb01181.x
Abstract
Blood group typing of an aged patient suffering from ileus provided evidence for an acquired B. As a parameter independent of cell membrane molecules or secreted blood group substances, the nucleotide sequence polymorphism of A and B transferases was investigated. Restriction fragment length polymorphism of DNA chains amplified in a polymerase chain reaction from the coding region of the glycosyltransferase indicated that no gene for B transferase was present in the patient's genome. We conclude that the assessment of polymorphism of AB0 blood group transferase can be used as a marker independent of blood group molecules for confirming a suspected acquired B.Keywords
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