BIOLOGICAL EFFECTS OF ANOREXIGENIC AND FAT-MOBILIZING SUBSTANCES FROM RAT URINE

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Abstract
An anorexigenic and fat-mobilizing substance (FMS I) previously extracted from the urine of fasting rats has been further fractionated, on the basis of solubility, in alkaline or neutral solutions respectively into FMS IA and FMS IB. When a single subcutaneous injection was administered to rats, FMS I and IA, but not IB, caused a decrease of food intake and of body weight; FMS I and IB, but not IA, caused an increase in serum free fatty acids and in liver fat. In addition, IB caused a significant increase in blood ketones. All three fractions caused hypoglycemia. From these observations, it is concluded that the anorexigenic property is associated with fraction IA and the fat-mobilizing properly is assocatied with fraction IB. FMS I is not excreted by rats during feeding at an environmental temperature of 24 °C but is excreted by fed rats during acute exposure to cold (5 °C), a situation in which fat mobilization is known to occur. Urine extracts from fasting, hypophysectomized rats contained no fat-mobilizing activity in vitro or in vivo.

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