An Efficient Synthesis of 4-Aryl-1,2,3,4-Tetrahydroisoquinolines
- 1 April 1994
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 24 (8) , 1187-1193
- https://doi.org/10.1080/00397919408011716
Abstract
An efficient synthesis of 4-aryl substituted 1,2,3,4-tetrahydroisoquinolines is described. Suzuki coupling of 4-bromoisoquinoline with arylboronic acids gives the 4-arylisoquinolines which can be reduced with NaBH3CN to the 1,2,3,4-tetrahydroisoquinolines.Keywords
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