Evaluation of phosphohexose isomerase activity in cerebrospinal fluid in neoplastic disease of the central nervous system

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Abstract
Phosphohexose isomerase activity has been measured in the cerebrospinal fluid in a control group of patients without demonstrable neoplastic disease and in patients with malignant and benign tumors cerebral thromboses, and infections of the central nervous system. The mean value of phosphohexose isomerase activity in the cerebrospinal fluid in the control series was 1.85 + 1.15, with a range of 0 to 4.2 units. Of 33 patients with primary or secondary tumors, 21 showed phosphohexose isomerase activity above the normal range. In these patients, no correlation was noted between the phosphohexose isomerase activity of cerebrospinal fluid and of serum. No correlation was observed between phosphohexose isomerase activity and protein and sugar concentrations or white and red cell counts in the cerebrospinal fluid. The phosphohexose isomerase activity was within normal limits in all but 1 patient with benign tumor. Elevations were observed in half the patients with meningitis and meningoencephalitis caused by pyogenic, viral, or yeast organisms. The enzyme activity was elevated in the acute infections and normal in the chronic or subacute processes. Phosphohexose isomerase activity was elevated in 2 of 9 patients with cerebral thrombosis.