ABNORMAL IODOPROTEINS IN THE BLOOD OF EUMETABOLIC GOITROUS ADULTS*

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Abstract
The serum of 5 eumetabolic goitrous adults was found to contain appreciable quantities of butanol-insoluble iodine. The thyroidal uptake of I131 was increased in these patients, but was suppressed by the administration of triiodothyronine. Three subjects exhibited concentrations of serum PBI127 and 72-hour PBI131 which were in the thyrotoxic range. Following administration of I131, from 26 to 60 per cent of serum radioactivity migrated in the albumin area during zonal electrophoresis of serum. This material was detectable as long as twenty-eight days after administration of the tracer dose. In the serum of normal subjects there was also a radioiodinated compound which migrated with albumin, but which was butanol-soluble and disappeared from the circulation within seven days after administration of I131. The abnormal moiety in the serum of the goitrous subjects was subjected to butanol extraction, hydrolysis, electrophoresis in the presence of Cohn fraction IV-6, chromatography in butanol water, salting-out by phosphate buffer, and precipitation with anti-human-albumin horse serum. The material appears to be an iodinated peptide or protein of thyroidal origin with several characteristics of an albumin.

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