Evidence That Glycolysis Contributes to Gastric Acid Secretion

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Abstract
In the presence of glucose, lactic acid production in the frog gastric mucosa is increased by reducing the pO2 and by histamine. At a pO2 of 60 mm. Hg the rate of acid secretion is in general increased and the rate of O2 consumption is reduced by the addition of glucose. The rate of acid secretion is reduced and the rate of O2 consumption may be increased by the removal of glucose. Apparently glycolysis can contribute energy for acid secretion at a low pO2. The ratio of moles of H+ secreted by oxidative processes to moles of O2 consumed for the purpose of secretion is not necessarily less than 4.

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