Choline Studies in Rats Following Whole-Body X-Irradiation

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Abstract
The LD50 30 days for female Sprague-Dawley albino rats weighing about 200 g. was 665 [plus or minus] 13 r in air or 858 [plus or minus] 17 r with backscatter. No significant change in urinary choline excretion was observed in rats following irradiation with 500 r with backscatter. No differences were seen between the plasma alcohol-ether soluble choline of rats killed 1, 2 or 4 wks. after irradiation with 500 r including backscatter or 4 wks. after irradiation with 650 r including backscatter and that of pair-fed controls. Plasma alcohol-ether soluble choline and P were increased in fasted rats 48 hrs. following severe irradiation. The liver was also larger in proportion to body wt., but the fat content of the organ was not raised. None of the effects observed was a satisfactory indicator of early radiation injury.