Excretion and Distribution of Lithium in the Dog

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Abstract
This study was prompted by reports of the toxic effect of ingestion of LiCl2 by humans. Analyses for Li in serum and urine were carried out, using the Perkin-Elmer flame photometer. It was found that large doses produced gastrointestinal irritation and other toxic symptoms in dogs. Injected Li has a volume of distribution closely approximating the total body water. Li is excreted at rates roughly proportional to serum concn. and largely independent of the rate of urine flow. The tubular reabsorption of Li bears a closer relation to the filtered Li load than to its serum concn. Li and K are excreted by different mechanisms.
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