First Synthesis of the Cytotoxic and Antifungal C14‐Amine (2S,3E,5Z)‐2‐Amino‐3,5,13‐tetradecatriene Isolated from the New Zealand Ascidian Pseudodistoma novaezelandiae
- 12 May 1993
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1993 (5) , 551-555
- https://doi.org/10.1002/jlac.199319930190
Abstract
The synthesis of (2S,3E,5Z)‐2‐amino‐3,5,13‐tetradecatriene [(S‐1)] with high enantiomeric purity in excellent overall yield is described. In the crucial step the stereogenic center was generated by nucleophilic addition of tert‐butyl carbamate to a planar‐chiral tetracarbonyliron(1 +) complex.Keywords
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