Determination of Total 14C Residues of Sarafloxacin in Eggs of Laying Hens
- 1 December 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 48 (12) , 6409-6411
- https://doi.org/10.1021/jf000518m
Abstract
[14C]Sarafloxacin was orally administered to six laying hens for five consecutive days. Eggs were collected for 15 days after the initial drug treatment. Egg yolk and egg albumen were separated and assayed for total radioactive residues (TRR) using a combustion oxidizer and scintillation counting techniques. Radioactivity was detected in egg yolk and egg albumen on the second day of dosing and reached a maximum at 24 h after drug withdrawal. Thereafter, the sarafloxacin TRR levels in egg albumen declined rapidly and were undetectable 2 days after the last dose, whereas the levels in egg yolk declined at a much slower rate and were undetectable 7 days after drug withdrawal. In both the egg albumen and yolk, HPLC analysis indicated that the parent sarafloxacin was the major component. Keywords: Fluoroquinolone; sarafloxacin; residues; eggKeywords
This publication has 6 references indexed in Scilit:
- Determination of Sarafloxacin Residues in Fortified and Incurred Eggs Using On-Line Microdialysis and HPLC/Programmable Fluorescence DetectionJournal of Agricultural and Food Chemistry, 1999
- Automated multi-residue isolation of fluoroquinolone antimicrobials from fortified and incurred chicken liver using on-line microdialysis and high-performance liquid chromatography with programmable fluorescence detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1999
- Modeling Drug Residue Uptake by Eggs: Evidence of a Consistent Daily Pattern of Contaminant Transfer into Developing Preovulatory YolksJournal of Food Protection, 1997
- Liquid Chromatography Combined with Tandem Mass Spectrometry for the Confirmation of Sarafloxacin in Catfish TissueAnalytical Chemistry, 1996
- Reservoir of quinolone residues in fishFood Additives & Contaminants, 1991
- Rapid Assay for Monitoring Residues of Enrofloxacin and Sarafloxacin in Fish Tissues by High Performance Liquid ChromatographyJournal of Liquid Chromatography, 1991