[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
- 16 April 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 5 (10) , 1559-1561
- https://doi.org/10.1039/b702995k
Abstract
The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.Keywords
This publication has 21 references indexed in Scilit:
- Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted OxazolesOrganic Letters, 2006
- A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocolsChemical Communications, 2006
- Microwave‐Assisted Suzuki Coupling Reactions with an Encapsulated Palladium Catalyst for Batch and Continuous‐Flow TransformationsChemistry – A European Journal, 2006
- A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assemblyChemical Communications, 2006
- Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modesOrganic & Biomolecular Chemistry, 2005
- Synthesis of Organic Compounds Using Polymer-Supported Reagents, Catalysts, and/or Scavengers in Benchtop Flow SystemsIndustrial & Engineering Chemistry Research, 2005
- Continuous Flow Techniques in Organic SynthesisChemistry – A European Journal, 2003
- New tools and concepts for modern organic synthesisNature Reviews Drug Discovery, 2002
- Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to AzidesThe Journal of Organic Chemistry, 2002
- Click Chemistry: Diverse Chemical Function from a Few Good ReactionsAngewandte Chemie International Edition in English, 2001