A Role of Glucose in the Production of Artificial Caries

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Abstract
Chemical detns. were made during incubation. Of the various chemical detns. made the change in alpha-amino acids seemed of particular interest. When glucose was present or when the medium was buffered at pH 4 without glucose, there was inhibition of deamination of the alpha-amino acids. Even though the chemistry was similar in these 2 expts., the carious lesion resulted only when glucose was present in the medium. The effect of glucose in caries production appears to be inhibited by buffering the media at a pH of 8 even though bacterial activity was present.