Male and Female Drosophila Germline Stem Cells: Two Versions of Immortality
Top Cited Papers
- 20 April 2007
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 316 (5823) , 402-404
- https://doi.org/10.1126/science.1140861
Abstract
Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite striking cellular and genetic similarities that suggest a common evolutionary origin, however, male and female GSCs also display important differences. Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production.Keywords
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