ANALYSIS OF CHANGES IN RED BLOOD CELL AND WHITE BLOOD CELL POPULATIONS IN C57BL/6 (A SJL)F1, C57BL/6 (CBA CBA/H-T6)F1, AND C57BL/6 DBA/1 MICE1

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Abstract
Allophenic mice (47) of 3 different types (C57BL/6 .tautm. (A .times. SJL), C57BL/6 .tautm. (CBA .times. CBA/H-T6) and C57BL/6 .tautm. DBA/1) were analyzed for changes in their peripheral white blood cell composition and hemoglobin composition with age. Of the 47 mice, 10 showed significant changes termed chimeric drift in one or the other or both of these parameters. These 10 mice were classified as unstable chimeras, as opposed to the 37 stable chimeras, which showed no apparent chimeric drift. There was an excellent correlation of peripheral white blood cell and hemoglobin compositions of the stable chimeras. The unstable chimeras showed little or no correlation of these 2 markers. Possible mechanisms of chimeric drift are discussed.