Osteoprotegerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development
Open Access
- 1 April 1999
- news
- Published by Wiley
- Vol. 77 (2) , 188-193
- https://doi.org/10.1046/j.1440-1711.1999.00815.x
Abstract
The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell–dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.Keywords
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