Modulation of transforming growth factor type beta action by activated ras and c-myc.
Open Access
- 1 July 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (7) , 2649-2652
- https://doi.org/10.1128/mcb.7.7.2649
Abstract
Transfection of C3H/10T1/2 cells with a c-myc gene resulted in the acquisition of responsiveness to transforming growth factor type beta. Cells transfected with an activated H-ras gene or an H-ras and c-myc gene, however, exhibited a transformed morphology and spontaneous soft-agar growth, a phenotype induced reversibly by transforming growth factor type beta in responsive fibroblasts.This publication has 19 references indexed in Scilit:
- Potentiation of growth factor activity by exogenous c-myc expression.Proceedings of the National Academy of Sciences, 1986
- Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibilityNature, 1986
- Transforming growth factor type β regulation of actin mRNAJournal of Cellular Physiology, 1986
- Oncogene-Induced Transformation of C3H 10T1/2 Cells Is Enhanced by Tumor PromotersScience, 1984
- High Efficiency DNA-Mediated Transformation of Primate CellsScience, 1983
- Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogeneNature, 1983
- Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenesNature, 1983
- Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virusNature, 1982
- Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras geneNature, 1982
- A new technique for the assay of infectivity of human adenovirus 5 DNAVirology, 1973