COMPARATIVE-STUDY ON RADIOSENSITIVITIES OF CULTURED CELL LINES DERIVED FROM SEVERAL HUMAN TUMORS UNDER HYPOXIC CONDITION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (3) , 357-362
Abstract
Three human cell lines, Burkitt lymphoma cells (P3HR-1), epidermoid cervical carcinoma cells (HeLa S3-1) and melanoma cells (HMV) were irradiated with 200 kV X-rays under 3 different O2 conditions. The values of D0 and D10-2 were estimated for survival curves, and the dose modifying factors (DMF) were calculated for oxygenated and hypoxic irradiation. DMF values for oxygenation were not different for each cell line, but those for hypoxia revealed considerable differences for the 3 cell lines. From the comparison of modifications due to variable O2 concentrations on the survival curves of Burkitt lymphoma cells with those of other resistant cells, the shoulder of the survival curves becomes larger with lowering of the O2 tension, and the D0 value increases followed by a decrease in the n value, while in oxygenation, the decrease in D0 value takes place after the n value becomes close to 1.