Suppression of Experimental Allergic Encephalomyelitis by Stress.

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Abstract
Summary Stress, in the form of restraint repeated throughout the experiment or during its first half, suppressed development of clinical and histologic signs of experimental allergic encephalomyelitis (EAE) in rats after intradermal challenge with encephalitogenic emulsion. Clinical signs, but not histologic lesions, were suppressed by restraint when the highly effective foot pad route of challenge was employed. Intraperitoneal injections of adjuvant also suppressed EAE in rats simultaneously challenged with encephalitogenic emulsion in the skin. It is suggested that suppression of EAE by intraperitoneal adjuvant was due to the stressful effects of the consequent sterile granulomatous peritonitis. Thus, the occurrence of granulomatous peritonitis may explain the failure to produce EAE when rats are challenged by intraperitoneal route with encephalitogenic emulsions that contain adjuvant.