Bradykinin‐induced transient accumulation of inositol trisphosphate in neuron‐like cell line NG 108‐15 cells
Open Access
- 25 February 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 181 (2) , 403-406
- https://doi.org/10.1016/0014-5793(85)80301-x
Abstract
Studies were undertaken to further elucidate the mechanism(s) by which bradykinin‐dependent phosphoinositide metabolism takes place in neuroblastoma × glioma hybrid NG108‐15 cells [(1984) J. Biol. Chem. 259, 10201–10207] using [3H]inositol‐labelled cells. Bradykinin produced net increases in the level of [3H]inositol phosphates, especially of [3H]inositol trisphosphate which is formed transiently and most rapidly. The results indicate that bradykinin activates a phosphodiesterase to break down phosphatidylinositol 4,5‐bisphosphate, generating two recently recognized intracellular messengers, 1,2‐diacylglycerol and inositol trisphosphate.Keywords
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