The dexamethasone suppression test in the clinical setting

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Abstract
The dexamethasone suppression test (DST) was administered to 47 inpatients on a clinical, nonresearch psychiatric unit who were diagnosed according to DSM-III [Diagnostic and Statistical Manual for Mental Disorders-III]. Of the 30 patients with major depression, 23 (77%) exhibited nonsuppression (serum cortisol concentrations > 5 .mu.g/dl); only 1 of the 17 patients with other diagnoses and depressive symptoms exhibited nonsuppression. There was no difference in the rate of nonsuppression between the patients with subgroups of major depression, but those with major depression and psychosis had significantly higher postdexamethasone cortisol levels than those with major depression with and without melancholia and those with diagnoses other than major depression.

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