Calibration of indicator dilution curves in man by the dynamic method.

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Abstract
The dynamic method of calibration of indicator dilution curves was based on comparison of the curve from a patient with a similar curve from an ancillary system in which the flow is known. The method previously gave satisfactory results in a model circulation and for the measurement of the cardiac output in dogs. Details of the use of the dynamic method in man were described. Close agreement between successive calibration curves indicate that the method was satisfactory. When a linear recording system was used there was no change in the calibration curve after injections of indicator. The application of the method to alinear recording systems was described. Reasonable agreement was shown between cardiac output measurements based on the Fick principle and indicator dilution curves calibrated by the dynamic method. The dynamic method is an accurate and convenient way to calibrate indicator dilution curves for the repeated measurement of the cardiac output in man.