THE EFFECT OF TOTAL BODY X-RADIATION ON 17 KETOSTEROID EXCRETION IN DOGS1

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Abstract
Attention has been drawn to alterations in adrenal cortical function in response to x-radiation (Narat, 1922; Jenkenson and Brown, 1944; Desjardins, 1928; Weichert, 1942; Hirsch, 1922; Selye, 1946). Histological and chemical alterations in the cortex in response to X-ray have been noted (Englestad and Torgerson, 1939; Weichert, 1942; Ellinger, 1948). Metabolic studies on patients exposed to X-ray have shown electrolyte changes which may be related to altered adrenal function (Goldman, 1943; Robertson, 1943). Several investigators have noted the absence of the indirect lymphopenic response to X-radiation in adrenalectomized animals (Leblond and Segal, 1942; Halberstaedler and Ichowicz, 1947; Dougherty and White, 1946). Lead shielding of the adrenal has been reported as having a positive effect on reducing the mortality to X-ray in a small number of male rats (Craver, 1946). Patt, et al., (1947) have shown changes in the adrenal cholesterol content and adrenal weight following LD50 and higher doses of radiation.