Effect of Adrenal Cortical Extract on the Blood Picture and Serum Proteins of Fowl

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Abstract
White Leghorn and New Hampshire Red fowl were injd. (subcut.) with aqueous adrenal cortical extracts (ACE),, White Leghorn laying hens showed leucopenia, absolute and relative increases in granulo-cytes and lymphocytes. Effects were maximal at 3 hrs. after injn. and the blood picture was normal after 24 hrs. New Hampshire non-laying pullets injd. with ACE showed similar changes with exception of leucopenia which was masked by increase in polymorphonuclears. The alterations are statistically significant. The effects of saline injns., 24-hr. fasting period, and saline plus fasting, are negligible. The 2 breeds of fowl showed quantitative differences in their reactions to ACE. ACE treatment produced no statistically significant change in total serum protein or serum globulin levels, although a trend in the direction of increase is indicated for the majority of injd. birds showing lymphopenia.