COMPARISON OF THE EFFECTS OF A NON-STEROIDAL ANTI-INFLAMMATORY AGENT, AN IMMUNOSUPPRESSIVE, A CORTICOSTEROID AND AN IMMUNOMODULATOR ON VARIOUS IMMUNOLOGICAL AND NON-IMMUNOLOGICAL INFLAMMATORY EXPERIMENTAL-MODELS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 242  (1) , 159-176
Abstract
The effects of a non-steroidal anti-inflammatory agent, phenylbutazone, a corticosteroid, desonide, an immunosuppressive, cyclophosphamide and an immunomodulator, levamisole on a number of experimental inflammatory models were compared. Compounds were first tested in carrageenan-induced pleurisy as a non-immune acute inflammation, then in passive skin anaphylaxis and reversed passive Arthus edema in the rat as models of humoral immunity. The compounds were investigated in various delayed hypersensitivity tests: reaction to sheep red cells and to oxazolone in the mouse, skin reaction to purified protein derivative (P.P.D.) in the rat and guinea-pig, P.P.D. induced pleurisy in the guinea-pig.